\magnification=1200 \baselineskip=20pt \nopagenumbers \font\big=cmr12 scaled \magstep2 \centerline{\bf STANFORD UNIVERSITY} \centerline{\bf DEPARTMENT OF STATISTICS} \centerline{\big DEPARTMENTAL SEMINAR} \bigskip \baselineskip=12pt \centerline{4:15 p.m., Tuesday, September 30, 2003} \centerline{Sequoia Hall Room 200} \centerline{(Cookies at 3:45 in 1st Floor Lounge)} \bigskip \baselineskip=15pt \centerline{\sl Rasmus Larsen} \centerline{\sl Informatics and Mathematical Modelling} \centerline{\sl Technical University of Denmark} \bigskip \centerline{\bf Biomedical Image Analysis - Analysis of Biological Appearance} \bigskip Abstract: I will present the active appearance model (AAM) proposed by Cootes \& Taylor for modelling the appearance of biological objects in images. This model is based on a truncated series of principal components and it is trained on images of biological objects (manually) annotated by sets of landmarks (corresponding points). I will illustrate the use of AAM for modelling and segmentation of images by examples including the human face, cardiac structures and brain structures. I will discuss 2 problems in relation to the application of AAM, 1) manual annotation of landmarks is tedious and error prone in 2D and insurmountable at realistic image resolutions in higher dimensions. Alternatively, training input may consist of curves and surfaces for which point correspondences can be established; 2) segmentation using AAM is based on relating the difference image between model and image to a change of parameters. For moderate resolution images in dimensions higher than 2 this becomes computationally infeasible. We therefore investigate the use of truncated wavelet and wedgelets bases to represent the images. \bye